Asian Journal of Pharmaceutical Research

M. Kranthi Kumar Reddy ¹, B. Narasimha Rao ¹, K. Ravindra Reddy ¹

Affiliations
1 Department of Pharmaceutics, P. Rami Reddy Memorial College of Pharmacy, Kadapa-516003, Andhra Pradesh, IN

Abstract

Nateglinide is a novel anti diabetic drug that lowers blood glucose levels by stimulating insulin secretion from the pancreas. This action is dependent upon functioning beta-cells in the pancreatic islets. One of the major problems with this drug is its low solubility in biological fluids, which results into poor bioavailability after oral administration. Therefore, solid dispersions (SDs) of nateglinide were prepared using lactose, mannitol and urea to increase its aqueous solubility. Nateglinide SDS was prepared in 1:1, 1:2, and 1:3 ratios of the drug to polymer (by weight). In vitro release profiles of all SDs (F-1 to F-9) were comparatively evaluated and also studied against pure Nateglinide. Faster dissolution was exhibited by solid dispersion containing 1:3 ratio of drug: mannitol. The increase in dissolution rate of the drug may be due to increase in wettability, hydrophilic nature of the carrier and due to reduction in drug crystallinity. The prepared solid dispersion was subjected for % practical yield, drug content and infrared (IR) spectroscopic studies. Absence of significant drug-carrier interaction was confirmed by infrared spectroscopic (IR) data.

Keywords

Nateglinide, Solid Dispersions (SDs), Mannitol, Urea, Lactose, Kneading Method.

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S. Sujani ¹, R. Hari Babu ¹, K. Ravindra Reddy ¹

Affiliations
1 Department of Pharmaceutics, P. Rami Reddy Memorial College of Pharmacy, Kadapa-516003, Andhra Pradesh, IN

Abstract

Spherical agglomerates of Meloxicam were prepared by simple agglomeration technique using a three solvent system. It includes a good solvent, a poor solvent and a bridging liquid. The selection of solvents depends on miscibility of the solvents and the solubility of drug in individual solvents. Accordingly acetone, water and chloroform are selected as a good solvent, poor solvent and bridging liquid. Chloroform has shown to be highly used in the preparation of spherical crystals. Hence this solvent system is used in the present study. Agglomerates were prepared by agitating the crystals in a liquid suspension and adding a bridging liquid, which wets the crystal surface causing binding. The addition of bridging liquid promotes the formation of liquid bridges between drug crystals. Spherical agglomerates of three different polymers (PVP, Poloxamer and Crosspovidone) and physical mixtures were prepared dried at room temperature. Particle size, saturation solubility, drug content, Fourier Transform Infrared Spectroscopy (FT-IR) studies and dissolution characteristics were also investigated.

Keywords

Meloxicam, Simple Agglomeration Technique, Spherical Agglomerates, PVP, Poloxamer and Crosspovidone.

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